Apamin-induced alterations in J774 1.6 macrophage metabolism

Phenobarbital-induced alterations in vitamin D metabolism.

The metabolic fate of intravenously injected vitamin D(3)-1,2-(3)H (D(3)-(3)H) was studied in two normal individuals on chronic phenobarbital therapy. Silicic acid column chromatography of lipid-soluble plasma extracts obtained serially for 96 hr after D(3)-(3)H injection demonstrated a decreased plasma D(3)-(3)H half-life and increased conversion to more polar metabolites. The polar metabolite...

ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS

35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. The patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. These changes appear to be related to the anticonvulsant drug taken, in the ...

Diabetes-induced Alterations in Renal Microcirculation and Metabolism

Diabetes-induced alterations in renal medullary microcirculation and metabolism.

Diabetes-induced renal complications, i.e. diabetes nephropathy, are a major cause of morbidity and mortality. The exact mechanisms mediating the negative influence of hyperglycemia on renal function are unclear, although several hypotheses have been postulated. Cellular mechanisms include glucose-induced excessive formation of reactive oxygen species, increased glucose flux through polyol path...

Alterations in Nuclear Ribonucleic Acid Metabolism Induced by Kinetin

Removal of deoxyribonucleic acid from meristematic onion root cells grown in solutions of kinetin, followed by metachromatic staining in azure B bromide, indicated the presence of appreciable amounts of ribonucleic acid in nuclei exposed to the cell division factor.